If I wait until the cutscene changes to inside the mission (e.g/ in the grineer/corpus ship) and THEN skip the cutscene, it doesn't crash.

One thing to note though, I've found that during loading transitions when going to dojos or missions, skipping the cutscene as the ship is shown flying to it's destination increases the chance of the game locking up. I'm very much doubting there's a problem with my Windows, since it was only installed 3 weeks ago and I've done nothing crazy with it. I've tried switching between classic and enhanced graphics modes, it crashes in both instances. Your specs are overkill for sure and the game still crashing, that's sucks dude :( I hope DE fix it as soon as possible. I can't see any reason, from my end, as to why the game is so horribly unstable right now. I'm running on a Ryzen 9 5950x processor with 32gb RAM, which is pure overkill for this kind of game, and an old Geforce GTX960 SSC, which I know is fairly old, but it can (and has for many years) easily handle this game.

Sometimes it'll be fine for a few hours, but other times it'll crash immediately when loading in to a mission right after launching the game. I've tried everything I can, from removing the auto-overclocking on my CPU, dropping the graphics down to potato mode, making sure all drivers are up-to-date, verifying and optimizing from the launcher, keeping an eye on temperatures, moving the game to an SSD, but still it crashes at random, and this isn't an infrequent occurrence, this is happening every 15 minutes or so. It's also crashed before when loading in other players while inside a dojo.

The most common is when loading in to a mission or a dojo, the whole game will simply freeze up and never unfreeze, making me have to force it to close via Steam. It seems to happen whenever the game needs to load something.

Warframe crashes windows 10 fix